原创力文档selective inhibitory effect of epigallocatechin-3-gallate on migration of vascular smooth muscle cellsepigallocatechin-3-gallate的选择性抑制作用在血管平滑肌细胞的迁移.pdfVIP
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selective inhibitory effect of epigallocatechin-3-gallate on migration of vascular smooth muscle cellsepigallocatechin-3-gallate的选择性抑制作用在血管平滑肌细胞的迁移
Molecules 2010, 15, 8488-8500; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Selective Inhibitory Effect of Epigallocatechin-3-gallate on
Migration of Vascular Smooth Muscle Cells
Dong-Wook Han 1,†, Mi Hee Lee 2,†, Byeong-Ju Kwon 2, Hye-Lee Kim 2, Suong-Hyu Hyon 3 and
Jong-Chul Park 2,*
1 Department of Nanomedical Engineering, College of Nanoscience Nanotechnology, Pusan
National University, Busan 609-735, Korea; E-Mail: nanohan@pusan.ac.kr (D-W.H.)
2 Brain Korea 21 Project for Medical Science, Cellbiocontrol Laboratory, Department of Medical
Engineering, Yonsei University College of Medicine, Seoul 120-752, Korea;
E-Mails: LEEMH1541@yuhs.ac (M.H.L.); bjlove123@yuhs.ac (B.J.K.); haley@yuhs.ac (H.L.K.)
3 Department of Medical Simulation Engineering, Research Center for Nano Medical Engineering,
Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan;
E-Mail: biogen@frontier.kyoto-u.ac.jp (S-H.H.)
† These authors contributed equally to this study.
* Author to whom correspondence should be addressed; E-Mail: parkjc@yuhs.ac;
Tel.: +82-2-2228-1917; Fax: +82-2-363-9923.
Received: 31 August 2010; in revised form: 13 November 2010 / Accepted: 17 November 2010 /
Published: 19 November 2010
Abstract: In order to prevent restenosis after angioplasty or stenting, one of the most
popular targets is suppression of the abnormal growth and excess migration of vascular
smooth muscle cells (VSMCs) with drugs. However,
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