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streptococcus mutans, caries and simulation models变形链球菌,龋齿和仿真模型
Nutrients 2010, 2, 290-298; doi:10.3390/nu2030290
OPEN ACCESS
nutrients
ISSN 2072-6643
/journal/nutrients
Review
Streptococcus mutans, Caries and Simulation Models
Sofia D. Forssten *, Marika Björklund and Arthur C. Ouwehand
Danisco Finland, Sokeritehtaantie 20, 02460 Kantvik, Finland;
E-Mail: marika.bjorklund@ (M.B.); arthur.ouwehand@ (A.C.O.)
* Author to whom correspondence should be addressed: E-Mail: sofia.forssten@;
Tel.:+35-840-536-7810, Fax: +35-892-982-203.
Received: 24 December 2009 / Accepted: 23 February 2010 / Published: 2 March 2010
Abstract: Dental caries and dental plaque are among the most common diseases
worldwide, and are caused by a mixture of microorganisms and food debris. Specific types
of acid-producing bacteria, especially Streptococcus mutans, colonize the dental surface
and cause damage to the hard tooth structure in the presence of fermentable carbohydrates
e.g., sucrose and fructose. This paper reviews the link between S. mutans and caries, as
well as different simulation models that are available for studying caries. These models
offer a valuable approach to study cariogenicity of different substrates as well as
colonization of S. mutans.
Keywords: Caries; Streptococcus mutans; carbohydrates; simulation; hydroxyapatite;
artificial saliva
1. Introduction
Dental caries is one of the most common and costly diseases in the world, and although ra
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