study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses新颖的合成化合物的生物活性的研究对人类鼻病毒具有抗病毒特性.pdfVIP

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study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses新颖的合成化合物的生物活性的研究对人类鼻病毒具有抗病毒特性.pdf

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study of the biological activity of novel synthetic compounds with antiviral properties against human rhinoviruses新颖的合成化合物的生物活性的研究对人类鼻病毒具有抗病毒特性

Molecules 2011, 16, 3479-3487; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Study of the Biological Activity of Novel Synthetic Compounds with Antiviral Properties against Human Rhinoviruses Samuela Laconi *, Maria A. Madeddu and Raffaello Pompei Sezione di Microbiologia Applicata, Università di Cagliari, via Porcell 4, 09124 Cagliari, Italy * Author to whom correspondence should be addressed; E-Mail: lsamuela@tiscali.it; Tel.: +39 0706758483; Fax: +39 070 6758482. Received: 9 February 2011; in revised form: 6 April 2011 / Accepted: 20 April 2011 / Published: 26 April 2011 Abstract: Picornaviridae represent a very large family of small RNA viruses, some of which are the cause of important human and animal diseases. Since no specific therapy against any of these viruses currently exists, palliative symptomatic treatments are employed. The early steps of the picornavirus replicative cycle seem to be privileged targets for some antiviral compounds like disoxaril and pirodavir. Pirodavir’s main weakness is its cytotoxicity on cell cultures at relatively low doses. In this work some original synthetic compounds were tested, in order to find less toxic compounds with an improved protection index (PI) on infected cells. Using an amino group to substitute the oxygen atom in the central chain, such as that in the control molecule