successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant hbv mutant成功的救援与替诺福韦治疗病人肝代谢失调和阿德福韦抗乙肝病毒变异.pdfVIP

successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant hbv mutant成功的救援与替诺福韦治疗病人肝代谢失调和阿德福韦抗乙肝病毒变异.pdf

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successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant hbv mutant成功的救援与替诺福韦治疗病人肝代谢失调和阿德福韦抗乙肝病毒变异

Comparative Hepatology BioMed Central Case Report Open Access Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant 1 2 1 1 Vlad Ratziu* , Vincent Thibault , Yves Benhamou and Thierry Poynard Address: 1Service dHépatogastroenterologie, Hôpital Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France and 2Laboratoire de Virologie, Hôpital Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France Email: Vlad Ratziu* - vratziu@teaser.fr; Vincent Thibault - vincent.thibault@psl.ap-hop-paris.fr; Yves Benhamou - ybenhamou@teaser.fr; Thierry Poynard - tpoynard@teaser.fr * Corresponding author Published: 11 January 2006 Received: 01 September 2005 Accepted: 11 January 2006 Comparative Hepatology 2006, 5:1 doi:10.1186/1476-5926-5-1 This article is available from: /content/5/1/1 © 2006 Ratziu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Prolonged adefovir therapy exposes to the emergence of adefovir resistant hepatitis B virus mutants. Initial reports of the rtN236T mutation showed preserved sensitivity to lamivudine; however, complex

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