successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant hbv mutant成功的救援与替诺福韦治疗病人肝代谢失调和阿德福韦抗乙肝病毒变异.pdfVIP
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successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant hbv mutant成功的救援与替诺福韦治疗病人肝代谢失调和阿德福韦抗乙肝病毒变异
Comparative Hepatology BioMed Central
Case Report Open Access
Successful rescue therapy with tenofovir in a patient with hepatic
decompensation and adefovir resistant HBV mutant
1 2 1 1
Vlad Ratziu* , Vincent Thibault , Yves Benhamou and Thierry Poynard
Address: 1Service dHépatogastroenterologie, Hôpital Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France and 2Laboratoire de
Virologie, Hôpital Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
Email: Vlad Ratziu* - vratziu@teaser.fr; Vincent Thibault - vincent.thibault@psl.ap-hop-paris.fr; Yves Benhamou - ybenhamou@teaser.fr;
Thierry Poynard - tpoynard@teaser.fr
* Corresponding author
Published: 11 January 2006 Received: 01 September 2005
Accepted: 11 January 2006
Comparative Hepatology 2006, 5:1 doi:10.1186/1476-5926-5-1
This article is available from: /content/5/1/1
© 2006 Ratziu et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Prolonged adefovir therapy exposes to the emergence of adefovir resistant hepatitis
B virus mutants. Initial reports of the rtN236T mutation showed preserved sensitivity to
lamivudine; however, complex
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