synthesis and antibacterial activities of 1-alkyl-3-methacryloyl (acryloyl) of benzimidazolone (thione) derivatives的合成及抗菌活性1-alkyl-3-methacryloyl(丙烯酰)benzimidazolone(thione)衍生品.pdfVIP

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synthesis and antibacterial activities of 1-alkyl-3-methacryloyl (acryloyl) of benzimidazolone (thione) derivatives的合成及抗菌活性1-alkyl-3-methacryloyl(丙烯酰)benzimidazolone(thione)衍生品.pdf

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synthesis and antibacterial activities of 1-alkyl-3-methacryloyl (acryloyl) of benzimidazolone (thione) derivatives的合成及抗菌活性1-alkyl-3-methacryloyl(丙烯酰)benzimidazolone(thione)衍生品

Int. J. Mol. Sci. 2012, 13, 4819-4830; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Synthesis and Antibacterial Activities of 1-Alkyl-3-methacryloyl (Acryloyl) of Benzimidazolone (Thione) Derivatives Shaopeng Wei, Wenjun Wu and Zhiqin Ji * College of plant protection and Institute of Pesticide Science, Northwest A F University, Shaanxi 712100, China; E-Mails: weishaopeng8888@163.com (S.W.); wuwenjun@ (W.W.) * Author to whom correspondence should be addressed; E-Mail: jizhiqin@; Tel.: +86-029 Fax: +86-029 Received: 7 March 2012; in revised form: 24 March 2012 / Accepted: 6 April 2012 / Published: 16 April 2012 Abstract: A series of (28) 1-alkyl-3-methacryloyl (acryloyl)-benzimidazolone (thione) deriv-atives were synthesized. The structures of the new derivatives were confirmed by 1H-NMR, 13C-NMR and ESI-MS spectral analysis. The antibacterial activities of these compounds against several strains of bacteria, such as Bacillus cereus, Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, were evaluated by methods of paper disc-diffusion and broth mciro-dilution. Methacryloyl derivatives displayed higher antibacterial activities against tested bacterial strains than those of acryloyl derivatives in in vi