原创力文档systematic literature review assessing tobacco smoke exposure as a risk factor for serious respiratory syncytial virus disease among infants and young children系统文献综述烟草烟雾暴露评估作为严重的呼吸道合胞体病毒疾病的风险因素在婴儿和年幼的孩子.pdfVIP
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systematic literature review assessing tobacco smoke exposure as a risk factor for serious respiratory syncytial virus disease among infants and young children系统文献综述烟草烟雾暴露评估作为严重的呼吸道合胞体病毒疾病的风险因素在婴儿和年幼的孩子
DiFranza et al. BMC Pediatrics 2012, 12:81
/1471-2431/12/81
RESEARCH ARTICLE Open Access
Systematic literature review assessing tobacco
smoke exposure as a risk factor for serious
respiratory syncytial virus disease among infants
and young children
1* 2 3 3 2
Joseph R DiFranza , Anthony Masaquel , Amy M Barrett , Ann D Colosia and Parthiv J Mahadevia
Abstract
Background: The role of environmental tobacco smoke (ETS) exposure as a risk factor for serious respiratory
syncytial virus (RSV) disease among infants and young children has not been clearly established. This systematic
review was conducted to explore the association between ETS exposure and serious RSV disease in children
younger than 5 years, including infants and young children with elevated risk for serious RSV disease.
Methods: A systematic review of English-language studies using the PubMed and EMBASE databases (1990–2009)
was performed to retrieve studies that evaluated ETS as a potential risk factor for serious RSV illness. Studies
assessing risk factors associated with hospitalization, emergency department visit, or physician visit due to RSV
(based on laboratory confirmation of RSV or clinical diagnosis of RSV) in children under the age of 5 years were
included.
Results: The literature search identified 30 relevant articles, categorized by laboratory confirmation of RSV infection
(n = 14), clinical diagnosis of RSV disease (n = 8), and assessment of RSV disease severity (n = 8). Across these three
categories of studies, at least 1 type of ETS exposure was associated with statistically significant increases in risk in
multivariate or bivariate analysis, as follows: 12 of 14 studies on risk of hospitalization or ED
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