systemic dizocilpine (mk-801) facilitates performance in opposition to response bias系统性dizocilpine(mk - 801)促进性能反对反应偏差.pdfVIP

Behavioral and Brain Functions BioMed Central Short paper Open Access Systemic dizocilpine (MK-801) facilitates performance in opposition to response bias Regan G Wisnewski and Johan Lauwereyns* Address: School of Psychology, Victoria University of Wellington, Wellington, New Zealand Email: Regan G Wisnewski - regan.wisnewski@vuw.ac.nz; Johan Lauwereyns* - jan.lauwereyns@vuw.ac.nz * Corresponding author Published: 19 September 2007 Received: 27 July 2007 Accepted: 19 September 2007 Behavioral and Brain Functions 2007, 3:48 doi:10.1186/1744-9081-3-48 This article is available from: /content/3/1/48 © 2007 Wisnewski and Lauwereyns; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Previous research has established that dopamine signals are crucial in orienting behavior to reward. Less is known, however, about the psychopharmacology of task performance under small-reward conditions as compared to large-reward conditions. The current study examined the effects of the noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist dizocilpine (MK-801) on reaction time (RT) in a nose-poke task with rats completing an asymmetric reward schedule. In all trials, the rats were required to poke their nose in either the left or the right peri