原创力文档targets and mechanisms of photodynamic therapy in lung cancer cells a brief overview光动力治疗在肺癌细胞靶点和作用机制简要概述.pdfVIP
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targets and mechanisms of photodynamic therapy in lung cancer cells a brief overview光动力治疗在肺癌细胞靶点和作用机制简要概述
Cancers 2011, 3, 1014-1041; doi:10.3390/cancers3011014
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
Targets and Mechanisms of Photodynamic Therapy in Lung
Cancer Cells: A Brief Overview
Angela Chiaviello †, Ilaria Postiglione † and Giuseppe Palumbo *
Department of Biologia e Patologia Cellulare e Molecolare ―L.Califano‖- UniversitàFederico II, Via
S. Pansini, 5 80131 Naples, Italy; E-Mails: angelachiaviello@libero.it (A.C.);
ilariapostiglione@interfree.it (I.P.)
† These authors contributed equally to this work.
* To whom correspondance should be addressed; E-Mail: palumbo@unina.it; Tel.: + 39 081 7463249.
Received: 31 December 2010; in revisedform: 20 February 2011 / Accepted: 1 March 2011 /
Published: 3 March 2011
Abstract: Lung cancer remains one of the most common cancer-related causes of death.
This type of cancer typically develops over a period of many years, and if detected at an
early enough stage can be eliminated by a variety of treatments including photodynamic
therapy (PDT). A critical discussion on the clinical applications of PDT in lung cancer is
well outside the scope of the present report, which, in turn focuses on mechanistic and
other aspects of the photodynamic action at a molecular and cellular level. The knowledge
of these issues at pre-clinical levels is necessary to develop, check and adopt appropriate
clinical protocols in the future. This report, besides providing general information, includes
a brief overview of present experimental PDT and provides some non-exhau
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