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the adams family of proteases new biomarkers and therapeutic targets for cancer亚当斯的蛋白酶家族新的癌症生物标志物和治疗目标
Duffy et al. Clinical Proteomics 2011, 8:9
/content/8/1/9 CLINICAL
PROTEOMICS
REVIEW Open Access
The ADAMs family of proteases: new biomarkers
and therapeutic targets for cancer?
1,2* 1,2 3 2,4 4 1,2
Michael J Duffy , Maeve Mullooly , Norma O’Donovan , Sumainizah Sukor , John Crown , Aisling Pierce and
Patricia M McGowan1,2
* Correspondence: michael.j. Abstract
duffy@ucd.ie
1Department of Pathology and The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion.
Laboratory Medicine, St. Vincent’s Forty gene members of the family have been identified, of which 21 are believed to
University Hospital, Dublin 4,
Ireland be functional in humans. As proteases, their main substrates are the ectodomains of
Full list of author information is other transmembrane proteins. These substrates include precursor forms of growth
available at the end of the article factors, cytokines, growth factor receptors, cytokine receptors and several different
types of adhesion molecules. Although altered expression of specific ADAMs has
been implicated in different diseases, their best-documented role is in cancer
formation and progression. ADAMs shown to play a role in cancer include ADAM9,
ADAM10, ADAM12, ADAM15 and ADAM17. Two of the ADAMs, i.e., ADAM10 and 17
appear t
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