原创力文档the capn10 gene is associated with insulin resistance phenotypes in the spanish population与胰岛素抵抗相关的capn10基因表型在西班牙人口.pdfVIP
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the capn10 gene is associated with insulin resistance phenotypes in the spanish population与胰岛素抵抗相关的capn10基因表型在西班牙人口
The CAPN10 Gene Is Associated with Insulin Resistance
Phenotypes in the Spanish Population
´ ´ 1 ´ ´ ´ 2 ´ 1 ´ ´ 2
Marıa E. Saez *, Jose L. Gonzalez-Sanchez , Reposo Ramırez-Lorca , Marıa T. Martınez-Larrad , Carina
2 ´ 3 ´ 1 ´ 1 ´ 2
Zabena , Alejandro Gonzalez , Francisco J. Moron , Agustın Ruiz , Manuel Serrano-Rıos
´ ´
1 Neocodex, Departamento de Genomica Estructural, Seville, Spain, 2 Hospital Clınico San Carlos, Departamento de Medicina Interna II, Madrid, Spain, 3 Centro Avanzado
´ ´ ´
de Fertilidad (CAF), Unidad de Reproduccion y Genetica Humana, Cadiz, Spain
Abstract
Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized world. Familial aggregation of
cardiovascular risk factors is a frequent finding, but genetic factors affecting its presentation are still poorly understood. The
calpain 10 gene (CAPN10) has been associated with type 2 diabetes (T2DM), a complex metabolic disorder with increased
risk of cardiovascular disease. Moreover, the CAPN10 gene has been associated with the presence of metabolic syndrome
(MS) in T2DM and in polycystic ovary syndrome (PCOS). In this work, we have analysed whether the polymorphisms
UCSNP44, -43, -19 and -63 are related to several cardiovascular risk factors in the context of MS. Molecular analysis of
CAPN10 gene was performed in 899 individuals randomly ch
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