原创力文档the ceacam1 expression is decreased in the liver of severely obese patients with or without diabetesceacam1表达式却降低了肝脏的严重肥胖患者有或没有糖尿病.pdfVIP
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the ceacam1 expression is decreased in the liver of severely obese patients with or without diabetesceacam1表达式却降低了肝脏的严重肥胖患者有或没有糖尿病
Lee Diagnostic Pathology 2011, 6:40
/content/6/1/40
RESEARCH Open Access
The CEACAM1 expression is decreased in the
liver of severely obese patients with or without
diabetes
Wonae Lee
Abstract
Background: Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic antigen-related cell
adhesion molecule 1 (CEACAM1) is an important candidate for causing insulin resistance.
Methods: The CEACAM1 expression was evaluated immunohistochemically in the liver tissues of 99 severely obese
or non-obese subjects with or without diabetes. The CEACAM1 expression was classified into two categories: a
normal expression or a decreased expression.
Results: The CEACAM1 expression was markedly decreased in the hepatocytes with macrovesicular steatosis.
A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. The incidence of a decreased CEACAM1
expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes
(p 0.05). The incidence of a decreased CEACAM1 expression was not different between the diabetic and
non-diabetic groups.
Conclusions: This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.
Background CEACAM1 protein is a cell-cell adhesion molecule
Diabetes is one of the most problematic diseases in the detected in the pericannalicular region of hepatocytes
world, and it is a group of metabolic disease sharing [9]. CEACAM1 is a liver-specific transmembrane gyco-
hyperglycemia. Approximately 90-95% of diabetic protein and it is also a substrate of insulin receptor in
patients have type 2 diabetes in which insulin resistance liver [10,11]. CEACAM1 is phosphorylated in resp
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