原创力文档the core apoptotic executioner proteins ced-3 and ced-4 promote initiation of neuronal regeneration in caenorhabditis elegans核心凋亡刽子手蛋白质ced-3 ced-4促进秀丽隐杆线虫的神经再生的起始.pdfVIP
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the core apoptotic executioner proteins ced-3 and ced-4 promote initiation of neuronal regeneration in caenorhabditis elegans核心凋亡刽子手蛋白质ced-3 ced-4促进秀丽隐杆线虫的神经再生的起始
The Core Apoptotic Executioner Proteins CED-3 and CED-
4 Promote Initiation of Neuronal Regeneration in
Caenorhabditis elegans
1.¤a 2.¤b 1 3
Berangere Pinan-Lucarre , Christopher V. Gabel *, Christopher P. Reina , S. Elizabeth Hulme ,
4 1 1 1 2 5
Sergey S. Shevkoplyas , R. Daniel Slone , Jian Xue , Yujie Qiao , Sarah Weisberg , Kevin Roodhouse ,
5 3 2 1
Lin Sun , George M. Whitesides , Aravinthan Samuel *, Monica Driscoll
1 Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America, 2 Department of Physics and Center for Brain
Science, Harvard University, Cambridge, Massachusetts, United States of America, 3 Department of Chemistry and Chemical Biology, Harvard University, Cambridge,
Massachusetts, United States of America, 4 Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, United States of America, 5 Department of
Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, United States of America
Abstract
A critical accomplishment in the rapidly developing field of regenerative medicine will be the ability to foster repair of
neurons severed by injury, disease, or microsurgery. In C. elegans, individual visualized axons can be laser-cut in vivo and
neuronal responses to damage can be monitored to decipher genetic requirements for regeneration. With an initial interest
in how local environments manage cellu
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