原创力文档the design, development, and evaluation of a prototypic, prosthetic venous valve设计、开发和评价被,假体静脉瓣膜.pdfVIP
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the design, development, and evaluation of a prototypic, prosthetic venous valve设计、开发和评价被,假体静脉瓣膜
BioMedical Engineering OnLine BioMed Central
Research Open Access
The design, development, and evaluation of a prototypic, prosthetic
venous valve
Matt T Oberdier and Stanley E Rittgers*
Address: Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA
Email: Matt T Oberdier - oberdiermt@; Stanley E Rittgers* - srittgers@
* Corresponding author
Published: 19 September 2008 Received: 6 June 2008
Accepted: 19 September 2008
BioMedical Engineering OnLine 2008, 7:25 doi:10.1186/1475-925X-7-25
This article is available from: /content/7/1/25
© 2008 Oberdier and Rittgers; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Chronic venous insufficiency is a serious disease for which there is no clearly
successful surgical treatment. Availability of a proven prosthetic vein valve could provide such an
option by reducing venous reflux while permitting normal antegrade flow.
Methods: A new prosthetic vein valve design has been developed which mimics the function of a
natural valve by ensuring complete closure of the leaflets with minimal obstruction for antegrade
flow. A 2:1 mock-up of the device was tested to evaluate its ability to prevent regurgitation and
several key modifications w
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