原创力文档the effect of immunomodulators on the immunogenicity of tnf-blocking therapeutic monoclonal antibodies a review的效果免疫调制剂对肿瘤坏死因子抑制剂中治疗性单克隆抗体的免疫原性审查.pdfVIP
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the effect of immunomodulators on the immunogenicity of tnf-blocking therapeutic monoclonal antibodies a review的效果免疫调制剂对肿瘤坏死因子抑制剂中治疗性单克隆抗体的免疫原性审查
Krieckaert et al. Arthritis Research Therapy 2010, 12:217
/content/12/5/217
R E V I E W
The ef ect of immunomodulators on the
immunogenicity of TNF-blocking therapeutic
monoclonal antibodies: a review
1 1 2 1
Charlotte Louise Maria Krieckaert* , Geertje Margret Bartelds , Willem Frederik Lems and Gerrit Jan Wolbink
standard ization of the assays used to measure anti-TmAb
Abstract
anti bodies, and the timing of the measurements make
Therapeutic monoclonal antibodies have immunogenicity a complex subject to investigate. Several
revolutionized the treatment of various inl ammatory studies in various infl ammatory diseases demonstrate the
diseases. Immunogenicity against these antibodies presence of anti-TmAb antibodies [1]. Table 1 gives an
has been shown to be clinically important: it is overview of the reported frequency of anti-TmAb
associated with shorter response duration because antibodies in infl ixi mab (antibodies to infl iximab, or
of diminishing concentrations in the blood and with ATIs) and in adali mumab (anti-adalimumab antibodies,
infusion reactions. Concomitant immunomodulators or AAAs) [2-22]. h e large variation in the percentages of
in the form of methotrexate or azathioprine reduced anti-TmAb antibodies measured could be related to the
the immunogenicity of therapeutic antibodies in diff erences in assays, duration of treatment, and the use
rheumatoid arthritis, Cro
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