原创力文档ursolic acid inhibits na+k+-atpase activity and prevents tnf-α-induced gene expression by blocking amino acid transport and cellular protein synthesis乌索酸抑制na + k + atp酶活性,防止tnf-α-induced基因表达通过阻断氨基酸运输和细胞的蛋白质合成.pdfVIP
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ursolicacidinhibitsnak-atpaseactivityandpreventstnf-α-inducedgeneexpressionbyblockingaminoacidtransportandcellularproteinsynthesis乌索酸抑制nakatp酶活性,防止tnf-α-induced基因表达通过阻断氨基酸运输和细胞的蛋白质合成
Biomolecules 2011, 1, 32-47; doi:10.3390/biom1010032
OPEN ACCESS
biomolecules
ISSN 2218-273X
/journal/biomolecules/
Article
+ +
Ursolic Acid Inhibits Na /K -ATPase Activity and Prevents
TNF-α-Induced Gene Expression by Blocking Amino Acid
Transport and Cellular Protein Synthesis
1 1 2 1 3
Tomonobu Yokomichi , Kyoko Morimoto , Nana Oshima , Yuriko Yamada , Liwei Fu ,
Shigeru Taketani 1, Masayoshi Ando 4 and Takao Kataoka 1,2,*
1 Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku,
Kyoto 606-8585, Japan; E-Mails: yokkon424@yahoo.co.jp (T.Y.);
morikyon-073128@m2.gyao.ne.jp (K.M.); yamada239@sekisui.jp (Y.Y.);
taketani@kit.ac.jp (S.T.)
2 Center for Biological Resources and Informatics, Tokyo Institute of Technology,
4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan; E-Mail:
nana.ooshima@to.shiseido.co.jp (N.O.)
3 Graduate School of Science and Technology, Niigata University, Igarashi 2-8501, Nishi-ku,
Niigata 950-2181, Japan; E-Mail: fu-liwei@mgc.co.jp (L.F.)
4 Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi 2-8501,
Nishi-ku, Niigata 950-2181, Japan; E-Mail: andomasa2@ksj.biglobe.ne.jp (M.A.)
* Author to whom correspondence should be addressed; E-Mail: takao.kataoka@kit.ac.jp;
Tel.: +81-75-724-7752; Fax: +81-75-724-7752.
Received: 20 August 2011; in revised form: 26 October 2011 / Accepted: 27 October 2011 /
Published: 7 November 2011
Abstract: Pro-in
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