原创力文档uropathogenic escherichia coli p and type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstructionuropathogenic大肠杆菌p和1型菌毛在生活主机协同行动,促进肾殖民导致肾元阻塞.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
uropathogenic escherichia coli p and type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstructionuropathogenic大肠杆菌p和1型菌毛在生活主机协同行动,促进肾殖民导致肾元阻塞
Uropathogenic Escherichia coli P and Type 1 Fimbriae
Act in Synergy in a Living Host to Facilitate Renal
Colonization Leading to Nephron Obstruction
1 2 1 1¤ 3
Keira Melican , Ruben M. Sandoval , Abdul Kader , Lina Josefsson , George A. Tanner , Bruce A.
2 1
Molitoris , Agneta Richter-Dahlfors *
1 Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Stockholm, Sweden, 2 Division of Nephrology, Department of Medicine,
Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 3 Department of Cellular and Integrative
Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Abstract
The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the
target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-
time as the infection progresses within an organ of a live host. Here we used multiphoton microscopy-based live animal
imaging, combined with advanced surgical procedures, to investigate the role of uropathogenic Escherichia coli (UPEC)
attachment organelles P and Type 1 fimbriae in renal bacterial infection. A GFP+ expressing variant of UPEC strain CFT073
and genetically well-defined isogenic mutants were microinfused into rat glomerulus or proximal tubules. Within 2 h
bacteria colonized along the flat squamous epithelium of the Bowman’s capsule despite being exposed to the primary
filtrate. When facing the challenge of the filtrate flow in the proxim
您可能关注的文档
- the impact of t cell intrinsic antigen adaptation on peripheral immune tolerance的影响t细胞内在抗原适应外周免疫耐受.pdf
- the impact of the absence of aliphatic glucosinolates on insect herbivory in arabidopsis没有脂肪族硫配糖体的影响在拟南芥昆虫取食.pdf
- the impact of the environment on health by country a meta-synthesis环境对健康的影响国家综合集成.pdf
- the impact of the national hiv health care worker hotline on patient care in south africa国家艾滋病医疗保健的影响在南非工人热线在病人护理.pdf
- the impact of the introduction of critical care outreach services in england a multicentre interrupted time-series analysis急救护理外展服务的引入的影响在英国多中心打断了时间序列分析.pdf
- the impact of the new who antiretroviral treatment guidelines on hiv epidemic dynamics and cost in south africa新世卫组织抗逆转录病毒治疗指南的影响在南非艾滋病毒流行动态和成本.pdf
- the impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability脓毒症的严重程度的影响在低血糖的风险和血糖的变化.pdf
- the impact of the species–area relationship on estimates of paleodiversitypaleodiversity物种-区域关系的估计的影响.pdf
- the impact of whaling on the ocean carbon cycle why bigger was better捕鲸在海洋碳循环的影响更大的更好的原因.pdf
- the impact of weather on influenza and pneumonia mortality in new york city, 1975–2002 a retrospective study天气对流感和肺炎死亡率的影响在纽约,1975 - 2002年的回顾性研究.pdf
- use of a dense single nucleotide polymorphism map for in silico mapping in the mouse使用密集的单核苷酸多态性在硅片映射的映射鼠标.pdf
- use of a generalized additive model to investigate key abiotic factors affecting microcystin cellular quotas in heavy bloom areas of lake taihu使用广义相加模型研究主要非生物因素影响国内外细胞配额在沉重的布鲁姆地区太湖.pdf
- use of a high resolution melting (hrm) assay to compare gag, pol, and env diversity in adults with different stages of hiv infection使用高分辨率融化(人力资源管理)分析比较插科打诨,波尔,env多样性成年人感染hiv病毒的不同阶段.pdf
- use of a mathematical model of autopoietic maintenance of pulmonary alveolar integrity to show a possible relationship between epithelial-mesenchymal transition and the genesis of emphysema and fibrosis英文论文.pdf
- use of a deuterated internal standard with pyrolysis-gcms dimeric marker analysis to quantify tire tread particles in the environment使用氘内部标准pyrolysis-gcms二聚的标记分析量化车轮踏面粒子在环境中.pdf
- use of a new cluster ansatz to treat strong relaxation and correlation effects a direct method for energy differences使用一个新的集群拟设来治疗效果强烈的放松和相关能量差异的直接法.pdf
- use of a naturally occurring codon bias for identifying topoisomerase mutations in ciprofloxacin resistant escherichia coli using pcr and future prospects with other bacterial genera a pilot study英文论文.pdf
- use of artificial intelligence to shorten the behavioral diagnosis of autism使用人工智能来缩短行为诊断自闭症.pdf
- use of biofungicides for controlling plant diseases to improve food availability使用控制植物病害biofungicides改善食品的可用性.pdf
- use of an atrial lead with very short tip-to-ring spacing avoids oversensing of far-field r-wave使用一个心房铅用短tip-to-ring间距避免步步文远场的非线性波.pdf
文档评论（0）