use of artificial intelligence to shorten the behavioral diagnosis of autism使用人工智能来缩短行为诊断自闭症.pdfVIP

Use of Artificial Intelligence to Shorten the Behavioral Diagnosis of Autism 1,2 1 3 1 1 Dennis P. Wall *, Rebecca Dally , Rhiannon Luyster , Jae-Yoon Jung , Todd F. DeLuca 1 Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, 3 Laboratories of Cognitive Neuroscience, Boston Children’s Hospital, Boston, Massachusetts, United States of America Abstract The Autism Diagnostic Interview-Revised (ADI-R) is one of the most commonly used instruments for assisting in the behavioral diagnosis of autism. The exam consists of 93 questions that must be answered by a care provider within a focused session that often spans 2.5 hours. We used machine learning techniques to study the complete sets of answers to the ADI-R available at the Autism Genetic Research Exchange (AGRE) for 891 individuals diagnosed with autism and 75 individuals who did not meet the criteria for an autism diagnosis. Our analysis showed that 7 of the 93 items contained in the ADI-R were sufficient to classify autism with 99.9% statistical accuracy. We further tested the accuracy of this 7-question classifier against complete sets of answers from two independent sources, a collection of 1654 individuals with autism from the Simons Foundation and a collection of 322 individuals with autism from the Boston Autism Consortium. In both cases, our classifier performed with nearly 100% statistical accuracy, properly categorizing all but one of the individuals from these two resources who previously had been diagnosed with autism through the standard ADI-R. Our ability to measure sp