uvb-protective effects of isoflavone extracts from soybean cake in human keratinocytesuvb-protective蛋糕从大豆异黄酮提取的影响在人类角质细胞.pdfVIP

Int. J. Mol. Sci. 2007, 8, 651-661 International Journal of Molecular Sciences ISSN 1422-0067 © 2007 by MDPI /ijms Full Research Paper UVB-Protective Effects of Isoflavone Extracts from Soybean Cake in Human Keratinocytes 1 1 2 3 3 Han-Sun Chiang , Wen-Bin Wu , Jia-You Fang , Bing-Huei Chen , Tsai-Hua Kao , Ying-Ting Chen 1, Chieh-Chen Huang 4 and Chi-Feng Hung 1,* 1 School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan 2 Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan 3 Department of Nutrition and Food Sciences, Fu-Jen Catholic University, Taipei Hsien, Taiwan 4 Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan * Author to whom correspondence should be addressed; E-mail: skin@.tw; Tel: +886 2 Fax: +886 2 Received: 14 May 2007; in Revised Form: 20 June 200 7 / Accepted: 28 June 2007 / Published: 11 July 2007 Abstract: It has been shown by chromatography that aglycone, glucoside, acetylglucoside and malonylglucoside isoflavone extracts prepared from soybean cake showed better antioxidant activities than isoflavone standards. Consequently, the aim of this study was to evaluate the protective effects of these isoflavone extracts against ultraviolet B (UVB)- induced keratinocyt