原创力文档vaccination against heterologous r5 clade c shiv prevention of infection and correlates of protection预防接种不同的分支c的r5 shiv感染和相关的保护.pdfVIP
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vaccination against heterologous r5 clade c shiv prevention of infection and correlates of protection预防接种不同的分支c的r5 shiv感染和相关的保护
Vaccination against Heterologous R5 Clade C SHIV:
Prevention of Infection and Correlates of Protection
1,2 1 1,2 1
Samir K. Lakhashe , Wendy Wang , Nagadenahalli B. Siddappa , Girish Hemashettar , Patricia
3 3 4,6 4,6 5,6 1
Polacino , Shiu-Lok Hu , Franc¸ois Villinger , James G. Else , Francis J. Novembre , John K. Yoon ,
1,2 7 1,2 . 1,2.
Sandra J. Lee , David C. Montefiori , Ruth M. Ruprecht * , Robert A. Rasmussen
1 Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 2 Harvard Medical School, Boston, Massachusetts, United States of America, 3 University
of Washington, Seattle, Washington, United States of America, 4 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta,
Georgia, United States of America, 5 Department of Microbiology, Emory University School of Medicine, Atlanta, Georgia, United States of America, 6 Yerkes National
Primate Research Center, Emory University, Atlanta, Georgia, United States of America, 7 Duke University, Durham, North Carolina, United States of America
Abstract
A safe, efficacious vaccine is required to stop the AIDS pandemic. Disappointing results from the STEP trial implied a need to
include humoral anti-HIV-1 responses, a notion supported by RV144 trial data even though correlates of protection are
unknown. We vaccinat
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