variability and diversity of nasopharyngeal microbiota in children a metagenomic analysis儿童鼻咽微生物群的变化和多样性宏基因组分析.pdfVIP

Variability and Diversity of Nasopharyngeal Microbiota in Children: A Metagenomic Analysis 1 2 3 4 5 1 Debby Bogaert *, Bart Keijser , Susan Huse , John Rossen , Reinier Veenhoven , Elske van Gils , Jacob 6 2 7,8 1 Bruin , Roy Montijn , Marc Bonten , Elisabeth Sanders 1 Department of Paediatric Infectious Diseases and Immunology, University Medical Center Utrecht-Wilhelmina Children’s Hospital, Utrecht, The Netherlands, 2 Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, TNO Quality of Life, Zeist, The Netherlands, 3 Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, United States of America, 4 Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands, 5 Linnaeus Institute, Spaarne Hospital, Hoofddorp, The Netherlands, 6 Regional Laboratory of Public Health, Haarlem, The Netherlands, 7 Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands, 8 Julius Center of Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands Abstract The nasopharynx is the ecological niche for many commensal bacteria and for potential respiratory or invasive pathogens like Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis. Disturbance of a balanced nasopharyngeal (NP) microbiome might be involved in the onset of symptomatic infections with these pathogens, which occurs primarily in fall and winter. It is unknown whether seasonal infection patterns are associated with concomitan