dna polymorphisms of the lipoprotein lipase gene and their association with coronary artery disease in the saudi population脂蛋白脂肪酶基因的dna多态性及其与冠状动脉疾病协会在沙特人口.pdfVIP

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dna polymorphisms of the lipoprotein lipase gene and their association with coronary artery disease in the saudi population脂蛋白脂肪酶基因的dna多态性及其与冠状动脉疾病协会在沙特人口.pdf

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dna polymorphisms of the lipoprotein lipase gene and their association with coronary artery disease in the saudi population脂蛋白脂肪酶基因的dna多态性及其与冠状动脉疾病协会在沙特人口

Int. J. Mol. Sci. 2012, 13, 7559-7574; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article DNA Polymorphisms of the Lipoprotein Lipase Gene and Their Association with Coronary Artery Disease in the Saudi Population Abdulaziz A. Al-Jafari 1,*, Mohamed S. Daoud 1, Abdulelah F. Mobeirek 2 and 1 Mohammad S. Al Anazi 1 Department of Biochemistry, Faculty of Science, King Saud University, 11451, Saudi Arabia; E-Mails: dr_mohamed301@ (M.S.D.); msanazi@.sa (M.S.A.A.) 2 Cardiac Sciences Department, Faculty of Medicine, King Saud University, 11472, Saudi Arabia; E-Mail: amobeirek@ * Author to whom correspondence should be addressed; E-Mail: ajafari@.sa; Tel.: +966-1-4675953; Fax: +966-1-4675791. Received: 20 March 2012; in revised form: 30 May 2012 / Accepted: 8 June 2012 / Published: 18 June 2012 Abstract: Coronary heart disease (CHD) is a major health problem and a major cause of death in most countries. Evidence has been presented that gene polymorphisms (HindIII, PvuII and Ser447Ter) of lipoprotein lipase (LPL) are risk factors of coronary artery disease (CAD). Aim: Our objective of the present investigation was to determine whether 3 LPL polymorphisms (LPL-HindIII, LPL-PvuII and LPL-Ser447Ter) can be considered as independent risk factors for CAD in the Saudi population. Methods: We recruited 120 CAD