dna-binding study of tetraaqua-bis(p-nitrobenzoato)cobalt(ii) dihydrate complex [co(h2o)4(p-no2c6h4coo)2]·2h2odna结合蛋白的研究tetraaqua-bis(p-nitrobenzoato)钴(ii)二水合物复杂[有限公司(h2o)4(p-no2c6h4coo)2]·2水.pdfVIP

dna-binding study of tetraaqua-bis(p-nitrobenzoato)cobalt(ii) dihydrate complex [co(h2o)4(p-no2c6h4coo)2]·2h2odna结合蛋白的研究tetraaqua-bis(p-nitrobenzoato)钴(ii)二水合物复杂[有限公司(h2o)4(p-no2c6h4coo)2]·2水.pdf

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dna-binding study of tetraaqua-bis(p-nitrobenzoato)cobalt(ii) dihydrate complex [co(h2o)4(p-no2c6h4coo)2]·2h2odna结合蛋白的研究tetraaqua-bis(p-nitrobenzoato)钴(ii)二水合物复杂[有限公司(h2o)4(p-no2c6h4coo)2]·2水

Int. J. Mol. Sci. 2007, 8, 564-571 International Journal of Molecular Sciences ISSN 1422-0067 © 2007 by MDPI /ijms Full Research Paper DNA-Binding Study of Tetraaqua-bis(p -nitrobenzoato)cobalt(II) Dihydrate Complex: [Co(H O) (p -NO C H COO) ]·2H O 2 4 2 6 4 2 2 Ali Arslantas 1,*, A. Kadir Devrim 2 and Hacali Necefoglu 1 1 Department of Chemistry, Faculty of Arts and Sciences, Kafkas University, 36300 Kars, Turkey; E-mail: hnecef@ 2 Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey; E-mail: devrim@ * Author to whom correspondence should be addressed: arsoz33@ Received: 27 March 200; in revised form: 25 May 2007 / Accepted: 4 June 2007 / Published: 27 June 2007 . Abstract: The interaction of [Co(H O) (p-NO C H COO) ] 2H O with sheep genomic 2 4 2 6 4 2 2 DNA has been investigated by spectroscopic studies and electrophoresis measurements. The interaction between cobalt(II) p -nitrobenzoate and DNA has been followed by gel electrophoresis while the concentration of the complex was increased from 0 to 14 mM. The spectroscopic study and electrophoretic experiments support the fact that the complex binds to DNA by intercalation via p -nitrobenz

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