dna-binding study of tetraaqua-bis(p-nitrobenzoato)cobalt(ii) dihydrate complex [co(h2o)4(p-no2c6h4coo)2]·2h2odna结合蛋白的研究tetraaqua-bis(p-nitrobenzoato)钴(ii)二水合物复杂[有限公司(h2o)4(p-no2c6h4coo)2]·2水.pdfVIP
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dna-binding study of tetraaqua-bis(p-nitrobenzoato)cobalt(ii) dihydrate complex [co(h2o)4(p-no2c6h4coo)2]·2h2odna结合蛋白的研究tetraaqua-bis(p-nitrobenzoato)钴(ii)二水合物复杂[有限公司(h2o)4(p-no2c6h4coo)2]·2水
Int. J. Mol. Sci. 2007, 8, 564-571
International Journal of
Molecular Sciences
ISSN 1422-0067
© 2007 by MDPI
/ijms
Full Research Paper
DNA-Binding Study of
Tetraaqua-bis(p -nitrobenzoato)cobalt(II) Dihydrate
Complex: [Co(H O) (p -NO C H COO) ]·2H O
2 4 2 6 4 2 2
Ali Arslantas 1,*, A. Kadir Devrim 2 and Hacali Necefoglu 1
1 Department of Chemistry, Faculty of Arts and Sciences, Kafkas University, 36300 Kars, Turkey;
E-mail: hnecef@
2 Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey;
E-mail: devrim@
* Author to whom correspondence should be addressed: arsoz33@
Received: 27 March 200; in revised form: 25 May 2007 / Accepted: 4 June 2007 /
Published: 27 June 2007
.
Abstract: The interaction of [Co(H O) (p-NO C H COO) ] 2H O with sheep genomic
2 4 2 6 4 2 2
DNA has been investigated by spectroscopic studies and electrophoresis measurements.
The interaction between cobalt(II) p -nitrobenzoate and DNA has been followed by gel
electrophoresis while the concentration of the complex was increased from 0 to 14 mM.
The spectroscopic study and electrophoretic experiments support the fact that the complex
binds to DNA by intercalation via p -nitrobenz
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