原创力文档dna-methylation profiling of fetal tissues reveals marked epigenetic differences between chorionic and amniotic samples胎儿组织的dna甲基化分析揭示了表观遗传绒毛膜和羊膜样本之间的差异.pdfVIP
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dna-methylation profiling of fetal tissues reveals marked epigenetic differences between chorionic and amniotic samples胎儿组织的dna甲基化分析揭示了表观遗传绒毛膜和羊膜样本之间的差异
DNA-Methylation Profiling of Fetal Tissues Reveals
Marked Epigenetic Differences between Chorionic and
Amniotic Samples
1 2 2 2 2
Christel Eckmann-Scholz , Susanne Bens , Julia Kolarova , Sina Schneppenheim , Almuth Caliebe ,
2 1,3 4 1 2
Simone Heidemann , Constantin von Kaisenberg , Monika Kautza , Walter Jonat , Reiner Siebert ,
Ole Ammerpohl2*
1 Department of Gynecology Obstetrics, Christian-Albrechts-University Kiel University Hospital Schleswig-Holstein, Kiel, Germany, 2 Institute of Human Genetics,
Christian-Albrechts-University Kiel University Hospital Schleswig-Holstein, Kiel, Germany, 3 Department of Obstetrics, Gynecology and Reproductive Medicine, Hannover
Medical School, Hannover, Germany, 4 Praxis of Human Genetics, Kiel, Germany
Abstract
Epigenetic mechanisms including DNA methylation are supposed to play a key role in fetal development. Here we have
investigated fetal DNA-methylation levels of 27,578 CpG loci in 47 chorionic villi (CVS) and 16 amniotic cell (AC) samples.
Methylation levels differed significantly between karyotypically normal AC and CVS for 2,014 genes. AC showed more
extreme DNA-methylation levels of these genes than CVS and the differentially methylated genes are significantly enriched
for processes characteristic for the different cell types sampled. Furthermore, we identified 404 genes differentially
methylated in CVS with trisomy 21. These genes were significantly enriched for high CG dinucleotid (CpG) content and
developmental processes associated with Down syndro
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