药学-常用抗生素与输液溶液的稳定性研究（Study on the stability of pharmaceutical antibiotics and infusion solutions）.docVIP

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药学-常用抗生素与输液溶液的稳定性研究（Study on the stability of pharmaceutical antibiotics and infusion solutions）.doc

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药学-常用抗生素与输液溶液的稳定性研究（Study on the stability of pharmaceutical antibiotics and infusion solutions）

药学-常用抗生素与输液溶液的稳定性研究（Study on the stability of pharmaceutical antibiotics and infusion solutions） [Key words] antibiotics; stability; compatibility [Abstract] to observe the compatible stability of common antibiotics. The changes of the content of compatibility of common antibiotics were observed under the condition of room temperature, and the appearance and pH value of compatibility liquid were observed. The mixed liquid colorless transparent temperature and time, no color change, bubbles and visible precipitate, stable pH value, indicating the compatibility unreasonable change, drug compatibility; on the other hand, the combination of poor stability At present, there are many kinds of clinical antibiotics, which are usually dissolved in salt and injected intravenously with other injections to treat [1]. We simulated the clinical drug concentration, the injection of common antibiotics and stability were investigated with common infusion solution, strengthen the evaluation of clinical medicine, to provide reference for clinical medication, to ensure the reasonable and effective application of drugs. 1 instrument and reagent UV-2401 UV spectrophotometer (SHIMADZU Japan); TG328B type photoelectric analytical balance (Shanghai balance instrument factory); pHS-3C digital pH meter (Shanghai Lida instrument factory); antibiotic control (China control of pharmaceutical and Biological Products Institute); antibiotic injection (Yang Zi River Pharmaceutical Group Co. Ltd.). 2 method Determination of 2.1 wavelength selected with various control amount of goods, the compatibility solution of approximately 8 mu g/ml and 12 mu g/ml antibiotic solution, using distilled water as blank, respectively in the 200~400 nm wavelength range scanning. The detection wavelength is selected at the maximum absorption wavelength according to various solutions and analyzed by linear equations. The establishment of precision weighing every antibiotic control amount of goods 2.2 linear equations, f