药学笔记（Pharmacy notes）.docVIP

药学笔记（Pharmacy notes） Sulfa drugs: the growth environment of the direct use of folic acid bacteria can not, but the use of aminobenzoic acid in the environment (PABA) and two hydrogen pteridine, glutamic acid in catalytic synthesis of dihydrofolate dihydrofolate synthase in bacteria under. The formation of dihydrofolate reductase in dihydrofolate tetrahydrofolate under tetrahydrofolate as one carbon transfer enzyme coenzyme involved in nucleic acid precursors (purine and pyrimidine) synthesis. Nucleic acids, however, are necessary for the growth and reproduction of bacteria. Sulfa drug chemical structure similar to PABA, can compete with PABA dihydrofolate synthetase, affecting dihydrofolate synthesis, thus inhibited bacterial growth and reproduction. Sulfa drugs are characterized by competitive inhibition. Sulfa drugs are the biggest feature is through the blood-brain barrier into the brain, the brain infection has therapeutic effect. Side effect is that the gastrointestinal stimulation, kidney damage. Sulfonamide is a traditional antibiotic. It has many advantages, such as wide spectrum, easy to use and low price. But when taking, we must pay attention to the following points. The process of absorption, distribution, metabolism, and excretion of ADME: drugs in vivo! In the process of drug prevention and cure, there is the relationship between human body and drug interaction. The study of the effects of drugs on the organism, namely, the effect of drugs on the physiological functions of the organism, is called pharmacodynamics. The pharmacokinetics of drugs, the transport and transformation of drugs in the body, and the law of drug concentration with time, are called pharmacokinetics. The absorption, distribution and excretion of drugs in the body refer to the transport of drugs in the body, while the metabolism of drugs in vivo is called drug conversion. In the process of drug prevention and cure, there is the relationship between human body and drug interaction. T