非线性混合效应模型在交叉设计等级资料分析中应用.docVIP

非线性混合效应模型在交叉设计等级资料分析中应用 　 作者：陈卫中，杨晓虹，陈朝琼，杨翔 【摘要】 Objective To explore the application of nonlinear mixed models in ordered categorical data of cross-over trial analysis and hence provide methodology reference.Method An example was illustrated by modeling nonlinear mixed models using the NLMIXED command of SAS.Results All parameters and their standard error were estimated,so every factor could be intuitionisticatty interpreted.Conclusion When subjects were estimated as random effects,not only the accuracy of the estimation was improved,but also covariates,such as the center,age,gender and basel