三种微生物血清抗体水平及冠状动脉病变支数关系.doc

三种微生物血清抗体水平及冠状动脉病变支数关系 　【摘要】 目的： 探讨巨细胞病毒（CMV）、肺炎衣原体（CP）、幽门螺杆菌（HP）感染与冠状动脉病变程度的关系。方法：应用荧光抗体法检测112例冠状动脉不同病变程度患者血清巨细胞病毒抗体（CMVIgM）、肺炎衣原体抗体（CPIgG、CPIgM）、幽门螺杆菌抗体（HPIgG、HPIgM）水平，并进行比较。结果：冠状动脉三支病变组CPIgG高于≤二支病变组（χ2=4197 P=004），而两组的CMVIgM、CPIgM、 HPIgG及HPIgM无差异（分别P=100，P=0436，P=0528，P=0739）；血清HPIgG、CPIgG均阳性与单纯血清HPIgG阳性或单纯血清CPIgG阳性患者比较冠状动脉三支血管病变患者多，（χ2=3717 P=0043，χ2=6601 P=001）。结论：冠状动脉病变程度与CP慢性感染有关；复合慢性感染（HP、CP）对血管病变的程度有影响。 【关键词】 冠状动脉病变程度；巨细胞病毒抗体；肺炎衣原体抗体；幽门螺杆菌抗体 【ABSTRACT】 Objective： To investigate the relation between chronic infection of microorganism and the severity of coronary artery stenosis. Methods：Cytomegalovirus antibody（CMVIgM）, Chamydia pneumoniae antibodies（CPIgG、CPIgM）and Helicobacter pylori antibodies（HPIgG、HPIgM）in 112 cases with coronary artery disease were test by fluorescenceantibody technique. Results： Patients with 3vessel CAD showed higher serum CPIgG levels than that of patients with less 3vessel CAD(P=004). There was no significant difference between two groups in CMVIgM, CPIgM, HPIgG and HPIgM(Pgt;005).The mixed infection of the two kinds of pathogen was higher than those caused by individual infection of any one kind of pathogen, and the difference had statistical significance(Plt;005). Conclusion： There are relations between chronic infection of CP and severity of coronary artery stenosis. The incidence of coronary heart disease caused by the mixed infection of the two kinds of pathogen is higher than that caused by individual infection of any one of pathogen. 【KEY WORDS】 Coronary artery stenosis； Cytomegalovirus antibody; Chamydia pneumoniae antibodies; Helicobacter pylori antibodies 近代研究表明，冠心病的发生、发展与炎症及感染有密切关系，如巨细胞病毒（CMV）、肺炎衣原体（CP），幽门螺杆菌（HP）及其他病原体引起的血管内皮炎症损伤等，包括多种微生物的混合感染[1]。本研究比较112例冠心病患者临床资料与检测血清巨细胞病毒抗体（CMVIgM）、肺炎衣原体抗体（CPIgG,CPIgM）及幽门螺杆菌抗体（HPIgG,HPIgM）水平的关系。 1 资料与方法 11 一般资料 病人为我院和北京朝阳医院20009~11月冠心病人112例，男性90例，女性22例；年龄范围 (平均6133±956)岁。其中≤二支病变组45例，男性 36 例，女性 9例；年龄范围(平均6115±999)岁。三支病变组67例，男性54例，女性13例；年龄范围(平均6147±912)岁。 12 诊断标准 冠脉造影判断冠状动脉狭窄程度采用