小儿抽动障碍及A组溶血性链球菌感染抗基底神经节抗体关系.docVIP

小儿抽动障碍及A组溶血性链球菌感染抗基底神经节抗体关系 　 作者：李冰，陈黎，黄铁栓，廖建湘，胡雁，扬亚平，翟洪顺 【摘要】 目的 探讨慢性抽动症和多发性抽动症与链球菌感染抗基底节抗体的关系。方法 采用酶联免疫吸附试验方法随机测定30例小儿抽动症血清抗基底节抗体(IgG)，并与20例对照组对比；同时测定二组病儿的链球菌感染证据，ASO(抗链球菌溶血素O)，ADNaseB(抗链球菌脱氧核糖核酸酶B)。 结果 病例组ASO阳性率为40%(12/30)，对照组为15%(3/20)，二组差异没有统计学意义(Pgt;0.05)。病例组ADNaseB阳性30.0%(9例)，对照组ADNaseB阳性5.0%(1例)，病例组和对照组ADNaseB阳性率之间的差异有统计学意义(Plt;0.05)。病例组抗基底节抗体阳性率30%(9/30)，对照组15%(3/20)，两组抗基底节抗体阳性率的差异无统计学意义(Pgt;0.05)。ADNaseB阳性和抽动症有统计学关联(P = 0.057)，其OR值为8.143(OR 95% CI：0.942~70.409)。 结论 部分小儿抽动症的病因可能与链球菌感染有关，尤其应注意检测ADNaseB。抗基底节抗体与链球菌感染的关系尚不肯定。 【关键词】 抽动症；链球菌感染；抗基底节抗体 ［Abstract］ Objective To study the relationship between chronic tic disorder/tourette syndrome and Group A streptococcal infection/antibodies to human basal ganglia.Methods Conducted enzyme-linked immunosorbent assay to detect antibodies to human basal ganglia of serum (IgG) of 30 children with tic disorders，which was compared with 20 non-infected disease children；and detected the streptococcal infection evidence，ASO (anti-streptolysin O)，ADNaseB (anti-DNase B) between the two groups of diseased children.Results The positive rate of ASO for the group of infected children was 40%(12/30).The positive rate of ASO for the comparison group was 15%(3/20).The difference between the two groups was statistically meaningless (Pgt;0.05).The positive rate of ADNaseB for the infected group was 30.0% (9 cases).The positive rate of ADNaseB for the comparison group was 5.0% (1 case).The difference of ADNaseB positive rate between the infected group and the comparison group was statistically meaningful (Plt;0.05).The positive rate of antibodies to human basal ganglia for the infected group was 30% (9/30).The positive rate of antibodies to human basal ganglia for the comparison group was 15%(3/20).The difference of positive rates of antibodies to human basal ganglia between the infected group and the comparison group was statistically meaningless (Pgt;0.05).ADNaseB positive rate had statistical relations (P= 0.057) with tic disorder