局部晚期鼻咽癌舌脉变化及治疗疗效分析.docVIP

局部晚期鼻咽癌舌脉变化及治疗疗效分析 　 作者：郭建新 娄鹏荣 陶庆松 徐正阳 陈俊 王锡恩 【摘要】 　　［目的］ 舌脉异常与恶性肿瘤的治疗和预后有相关性，放疗配以化疗是治疗局部晚期鼻咽癌可能根治的有效方法，但是仍有较大部分患者出现局部复发以及远处转移，通过研究舌脉的变化探讨局部晚期鼻咽癌治疗预后因素。［方法］将68例进入同步根治性放化疗的局部晚期鼻咽癌分为舌脉正常组A组和舌脉异常组B组，采用常规放疗技术，放疗第一天开始同步PF 方案化疗二周期，放疗后二周开始辅助化疗二周期，隔28天一周期。［结果］ A组、B组五年生存率分别为513％、477％，组间差别无统计学意义；A组、B组五年无远处转移率分别为752％、605％，A组显著高于B组（Plt;005）。［结论］舌脉是否异常对局部晚期鼻咽癌病人的五年生存率无显著影响，但可能对无远处转移率有影响。提示舌脉变化可作为鼻咽癌病人是否易发生远处转移的指标之一。 【关键词】 鼻咽癌 舌脉 同步放化疗 　　Abstract: ［Objective］ The abnormity of glossal venation was always correlative with the therapy and prognosis of carcinoma. For locally advanced nasopharyngeal carcinoma, radiotherapy combined with chemotherapy is the potent radical method, but locoregional recurrence and distant metastasis occur in many patients. This study wants to discuss the prognosis of treatment by observing the change of glossal venation. ［Methods］ 68 patients with locally nasopharyngeal carcinoma who received concurrent chemoradiotherapy were divided into two arms: normal glossal venation (arm A) and abnormal glossal venation (arm B). All patients were received conventional radiotherapy, and chemotherapy (cisplatin/fluorouracil) was given concurrently, after two weeks of radiotherapy, patients were received two cycles chemotherapy again. The 5year overall survival rates and free distant metastases rate were observed.［Results］ The 5year overall survival rates were 513% for arm A and 477% for arm B, no significant difference in two arms; the 5year free distant metastases rate in arm A was 752%, compared with 605% in arm B (Plt;005). ［Conclusion］ The glossal venation abnormal or not was no significant effect in 5year overall survival rate of patients with locally advanced nasopharyngeal carcinoma, but can affect the free distant metastases rate of them possibly. It suggested that the change of glossal venation of patients with NPC would be one of indexes to estimate the distant metastases. 　　Key words:nasopharyngeal carcinoma;tongue vein;concurrent radiother