影响突聋疗效相关因素分析.docVIP

影响突聋疗效相关因素分析 　作者：邹苑斌　黄健男　刘庆好　郑明奋　刘玲中　彭树之 [摘要] 目的：探讨突聋的发病时间、年龄及眩晕对疗效的影响。方法：收集听力损失程度不同、病程长短不同、发病年龄不同及伴随有无眩晕的突聋患者150例，采用以前列腺素E1为主药，以扩血管、神经营养药为辅助治疗，观察上述因素与疗效关系，治疗前后行听力学检查对照。结果：病程小于2周内就治的轻中重度耳聋患者其有效率达97.22%；起病大于3个月就治者，其有效率为58.33%。从年龄看45岁之内者有效率为91.91％；46～60岁者有效率为85.36％；大于60岁以上者有效率75.00％。伴随症状看，伴有眩晕者有效率60.86％；不伴眩晕者有效率94.48％。结论：突聋的疗效与治疗时间成正比应越早疗效越好、反之越差；以中青年发病者治疗效果佳，伴眩晕的疗效差，不伴眩晕的疗效好。 [关键词] 突聋；相关因素；疗效 　　[Abstract] Objective：To study the influence of related factors on therapeutic effect of idiopathic sudden sensorineural hearing loss (ISSHL), including the time of attack, age of patients, vertigo accompanied or not. Methods：One hundred-fifty patients were collected, who are different in the degree of hearing-loss, course of disease and age of attack. All patients received treatment with PG-E1, applied by vasodilating medicines and neurotrophic medicines simultaneously. Relationships between these factors above-mentioned and therapeutic effect were analyzed, according to the results of audiology made before and after therapy. Results：The effective rate in patients whose course of disease is less than 2 weeks and exceed 3 month was 97.22% and 58.33%, respectively. Effective rate of different age including within 45, 46~60, above 60~years was 91.91%, 85.36%, 75.00% respectively. Effective rate of patients accompanied with vertigo or not was 60.86% or 94.48%. Conclusion：Therapeutic effect and time of therapy have a direct-ratio relationship. More early accepted therapy, more better is the effect. Young and middle age patients have better effect. The effect of patients without vertigo is better than that with vertigo. 　　[Key words] Idiopathic sudden sensorineural hearing loss； Correlation factor； Therapeutic effect 　　 　　突聋又称突发性感音神经性耳聋，是一种原因不明的在短时间内听力突然下降为主伴耳鸣或眩晕等症状的疾病，目前其发病率有逐年增加趋势，约为十万分之八到十四；如果诊断治疗不及时或不当，导致永久性的听力障碍或耳鸣，给病人带来极大的痛苦和不便。笔者通过发病时间、发病年龄及其伴随症状分析疗效关系，探讨其发病机制、可能发生的病因与治疗结果，指导临床治疗，提高突聋的治愈率。 　　1资料与方法 　　1．1临床资料 　　本院自2001~2007年收集150例突发性感音神经性耳聋的住院患者，此类病人经耳鼻咽喉科常规检查、纯音测听及声导