一类抗肿瘤新药洛铂体腔灌注化疗的研究进展-药学进展.PDF

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 12 :892-896 892 ( ) 一类抗肿瘤新药洛铂体腔灌注化疗的研究进展 1 2* 1 3** 何达伟 ，隋东虎 ，刘潇琨 ，吴强 （1. 海 南 长 安 国 际 制 药 有 限 公 司 注 册 部， 海 南 海 口 570314；2. 贵 州 益 佰 制 药 股 份 有 限 公 司 医 学 部， 贵 州 贵 阳 550008； 3. 南京医科大学附属肿瘤医院江苏省肿瘤医院妇瘤科，江苏 南京 210009） [ 摘要 ] 洛铂是第三代铂类抗肿瘤新药。大量研究表明，洛铂应用于体腔灌注化疗，与顺铂相比疗效相当或更高，且安全性和耐受性更好； 对于既往接受过其他铂类药物体腔灌注化疗失败的患者，洛铂的疗效肯定，且不良反应轻微。洛铂是体腔灌注化疗的理想药物。综述洛铂 体腔灌注化疗的临床研究进展。 [ 关键词 ] 洛铂；恶性积液；体腔灌注 [ 中图分类号 ] R979.1 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2014）12-0892-05 Research Progress in the New Antitumor Drug Lobaplatin for Body Cavity Perfusion Chemotherapy 1 2 1 3 HE Dawei , SUI Donghu , LIU Xiaokun , WU Qiang ( 1.The Registration Department, Hainan Changan International Pharmaceutical Co.,Ltd., Haikou 570314, China; 2. Department of Medicine,Guizhou Yibai Pharmaceutical Co.,Ltd., Guiyang 550008, China; 3. Department of Gynecological Oncology, Jiangsu Cancer Hospital, Cancer Hospital Affiliated to Nanjing Medical University, Nanjing 210009, China) [Abstract] As the third generation platinum drug, lobaplatin is safe and effective for intracavitary instillation, compared with cisplatin, and having safety and tolerability than cisplatin. For those who had received prior platinum-body cavity infusion chemotherapy, lobaplatin is also effective, with mild adverse reactions. Lobaplatin is the ideal drug for intracavitary instillation. The new progresses of clinical studies for intracavitary instillation on malignant pleuroperitoneal cavity hydrops were reviewed. [Key words] lobaplatin; malignant pleuroperitoneal; intracavitary instillation 恶性体腔（胸腔、腹腔、心包腔等）积液是晚期恶