大脑快速t1图谱成像研究 the study of fast t1 mapping of human brain.pdfVIP

第 5 卷 第4期 集 成 技 术 Vol. 5 No. 4 2016年7月 JOURNAL OF INTEGRATION TECHNOLOGY Jul. 2016 大脑快速 T1 图谱成像研究 江 克 钟耀祖  吴 垠  朱燕杰 (中国科学院深圳先进技术研究院 深圳 518055) 摘  要  大脑快速 T1 图谱成像是一种量化磁共振成像技术，可以为帕金森、癫痫、肝脑病等脑部疾病 的诊断提供重要参考依据。现有的大脑快速 T1 图谱成像技术可以将成像速度提高到几秒/层，然而主磁 场、发射场的不均性(尤其在高场下)以及大脑内部结构的磁化率差异，降低了成像精确性，限制了其在 临床上的推广应用。针对上述缺点，文章提出一种基于 TurboFLASH 技术的大脑快速 T1 图谱成像方法， 并先后在计算机仿真实验、仿体以及人体试验中进行验证。实验结果表明，文章提出的方法测得的大脑 组织 T1 值与金标准及文献中报导的值非常接近(误差＜3%)，同时扫描速度提高到 3 秒/层，空间分辨率 为 1.1 mm ×1.1 mm×4 mm，2 分钟内即可完成全脑采集。 关键词  T1 图谱；快速成像；大脑 T1 图谱 中图分类号  N 34 文献标志码  A The Study of Fast T1 Mapping of Human Brain JIANG Ke CHUNG Yiu-Cho WU Yin ZHU Yanjie ( Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China ) Abstract Fast brain T1 mapping is a quantitative technique of magnetic resonance imaging, and can provide important reference for the diagnosis of several brain diseases, such as Parkinson, epilepsy and hepatic encephalopathy. Fast T1 mapping techniques proposed previously had sped up acquisition to several seconds per slice. However, most of these techniques suffered seriously from the field inhomogeneity of main field, transmit field and susceptibility artifacts, which decreased the imaging accuracy and limited the clinic applications. To overcome the above mentioned shortcomings, we proposed a fast brain T1 mapping technique based on TurboFLASH and evaluated it on computer simulation, phantom experiment, and human brain T1 mapping. Results showed that T1 values from the proposed method were very close to the gold standard and literature (differences being less