impact on postpartum hemorrhage of prophylactic administration of oxytocin 10?iu via unijecttm by peripheral health care providers at home births design of a community-based cluster-randomized trial英文论文.pdfVIP
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impact on postpartum hemorrhage of prophylactic administration of oxytocin 10?iu via unijecttm by peripheral health care providers at home births design of a community-based cluster-randomized trial英文论文
Stanton et al. BMC Pregnancy and Childbirth 2012, 12:42
/1471-2393/12/42
STUDY PROTOCOL Open Access
Impact on postpartum hemorrhage of
prophylactic administration of oxytocin 10 IU via
UnijectTM by peripheral health care providers at
home births: design of a community-based
cluster-randomized trial
1* 2 1 3 2
Cynthia K Stanton , Samuel Newton , Luke C Mullany , Patience Cofie , Charlotte Tawiah Agyemang ,
Edward Adiibokah2 4 5 5 6 7
, Niamh Darcy , Sadaf Khan , Alice Levisay , John Gyapong , Deborah Armbruster and
Seth Owusu-Agyei2
Abstract
Background: Hemorrhage is the leading direct cause of maternal death globally. While oxytocin is the drug of
choice for postpartum hemorrhage prevention, its use has generally been limited to health facilities. This trial
assesses the effectiveness, safety, and feasibility of expanding the use of prophylactic intramuscular oxytocin to
peripheral health care providers at home births in four predominantly rural districts in central Ghana.
Methods: This study is designed as a community-based cluster-randomized trial in which Community Health
TM
Officers are randomized to provide (or not provide) an injection of oxytocin 10 IU via the Uniject injection system
within one minute of delivery of the baby to women who request their presence at home at the onset of labor.
The primary aim is to determine if administration of prophylactic oxytocin via Uniject™ by this cadre will reduce the
risk of postpartum hemorrhage by 5
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