the pneumonia virus of mice (pvm) model of acute respiratory infection肺炎病毒的小鼠急性呼吸道感染(pvm)模型.pdfVIP

Viruses 2012, 4, 3494-3510; doi:10.3390/v4 123494 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review The Pneumonia Virus of Mice (PVM) Model of Acute Respiratory Infection Kimberly D. Dyer 1,*, Katia E. Garcia-Crespo 1, Stephanie Glineur 1, Joseph B. Domachowske 2 1 and Helene F. Rosenberg 1 Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; E-Mails: garciacrespoke@ (K.E.G.-C.); stephanie.glineur@ (S.G.); hrosenberg@ (H.F.R.) 2 Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA; E-Mail: domachoj@ * Author to whom correspondence should be addressed; E-Mail: kdyer@; Tel.: +1-302-402-2429; Fax: +1-301-480-8384. Received: 7 November 2012; in revised form: 28 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012 Abstract: Pneumonia Virus of Mice (PVM) is related to the human and bovine respiratory syncytial virus (RSV) pathogens, and has been used to study respiratory virus replication and the ensuing inflammatory response as a component of a natural host—pathogen relationship. As such, PVM infection in mice reproduces many of the clinical and pathologic features of the more severe forms of RSV infection in human infants. Here we review some of the most recent findings on the basic biology of PVM infection and its use as a model of disease, most notably for explorations of virus infection and allergic airways diseas