the polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries聚胺抑制剂alpha-difluoromethylornithine调节hippocampus-dependent功能单一和组合后受伤.pdfVIP

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the polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries聚胺抑制剂alpha-difluoromethylornithine调节hippocampus-dependent功能单一和组合后受伤.pdf

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the polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries聚胺抑制剂alpha-difluoromethylornithine调节hippocampus-dependent功能单一和组合后受伤

The Polyamine Inhibitor Alpha-Difluoromethylornithine Modulates Hippocampus-Dependent Function after Single and Combined Injuries Susanna Rosi1,3,4, Ryan Ferguson1,3,4, Kelly Fishman1,4, Antino Allen1,4, Jacob Raber5,6,7, John R. Fike1,2,4* 1 Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America, 2 Department of Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America, 3 Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California, United States of America, 4 Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California, United States of America, 5 Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States of America, 6 Department of Neurology, Oregon Health and Science University, Portland, Oregon, United States of America, 7 Division of Neuroscience, Oregon National Primate Research Center (ONPRC), Oregon Health and Science University, Portland, Oregon, United States of America Abstract Exposure to uncontrolled irradiation in a radiologic terrorism scenario, a natural disaster or a nuclear battlefield, will likely be concomitantly superimposed on other types of injury, such as trauma. In the central nervous system, radiation combined injury (RCI) involving irradiation and traumatic brain injury may have a multifaceted character. This may entail cellular and molecular changes that are associated with cognitive performance, including changes in neurogenesis and the expression of the plasticity-related immediate early gene Arc. Because traumatic stimuli initiate a characteristic early increase in polyamine metabolism, we hypothesized that treat