原创力文档the reversal of drug-resistance in tumors using a drug-carrying nanoparticular system耐药性的逆转肿瘤使用drug-carrying nanoparticular系统.pdfVIP
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the reversal of drug-resistance in tumors using a drug-carrying nanoparticular system耐药性的逆转肿瘤使用drug-carrying nanoparticular系统
Int. J. Mol. Sci. 2009, 10, 3776-3792; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
The Reversal of Drug-Resistance in Tumors Using a
Drug-Carrying Nanoparticular System
Kyung Taek Oh 1,#, Hye Jung Baik 2,#, A Hyeong Lee 2, Young Taik Oh 3, Yu Seok Youn 4 and
Eun Seong Lee 2,*
1 College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Seoul 155-756, Korea;
E-Mail: kyungoh@cau.ac.kr (K.T.O.)
2 Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu,
Bucheon-si, Gyeonggi-do 420-743, Korea; E-Mails: hinakira@ (H.J.B.);
mathcap3@ (A.H.L.)
3 Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-ku
Shinchon-dong 134, Seoul, 120-752, Korea; E-Mail: oytaik@yumc.yonsei.ac.kr (Y.T.O.)
4 College of Pharmacy, Pusan National University, Jangjun-dong, Geumjeong-gu, Busan 609-735,
Korea; E-Mail: ysyoun@pusan.ac.kr (Y.S.Y.)
# These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: hejulu@ (E.S.L);
Tel. +82-2-2164-4921; Fax: +82-2-2164-4865.
Received: 4 August 2009 / Accepted: 26 August 2009 / Published: 31 August 2009
Abstract: Medical applications of nanoparticular systems have attracted considerable
attention because of their potential use in therapeutic targeting of disease tissues and their
lower level of toxicity against healthy tissue, relative to traditional pharma
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