原创力文档the role of biomarkers in community-acquired pneumonia predicting mortality and response to adjunctive therapy生物标志物的角色在社区获得性肺炎死亡率预测和响应辅助治疗.pdfVIP
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the role of biomarkers in community-acquired pneumonia predicting mortality and response to adjunctive therapy生物标志物的角色在社区获得性肺炎死亡率预测和响应辅助治疗
Available online /content/12/S6/S5
Review
The role of biomarkers in community-acquired pneumonia:
predicting mortality and response to adjunctive therapy
1 1 2
Jean-Paul Mira , Adeline Max and Pierre-Regis Burgel
1Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique, Hôpitaux de Paris, Université Paris Descartes, and INSERM U567, Paris
75014, France
2Pneumology Department, University Hospital, Assistance Publique, Hôpitaux de Paris, Université Paris Descartes, Paris 75014, France
Corresponding author: Jean-Paul Mira, jean-paul.mira@cch.aphp.fr
Published: 26 November 2008 Critical Care 2008, 12(Suppl 6):S5 (doi:10.1186/cc7028)
This article is online at /content/12/S6/S5
© 2008 BioMed Central Ltd
Abstract Although CAP is very common, it remains a common cause of
Patients with community-acquired pneumonia (CAP) in the hospital death. Hence, severe CAP has been reported to be the
setting exhibit markedly abnormal levels of various biomarkers of largest single cause of mortality from infectious diseases in
infection, inflammation and coagulation. CAP is a well charac- industrialized countries [4]. For example, a study conducted
terized disease, relatively homogeneous and amenable to manage- in the USA compared outcomes in more than 150,000
ment according to defined protocols. Hence, this group of patients patients aged over 65 years who were hospitalized for CAP
represents an opportunity to investigate further these b
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