the role of early life experience and species differences in alcohol intake in microtine rodents早期的生活经验和物种的角色差异饮酒microtine啮齿动物.pdfVIP

The Role of Early Life Experience and Species Differences in Alcohol Intake in Microtine Rodents 1 2 3 1 Allison M. J. Anacker , Todd H. Ahern , Larry J. Young , Andrey E. Ryabinin * 1 Department of Behavioral Neuroscience, Oregon Health Science University, Portland, Oregon, United States of America, 2 Center for Behavioral Neuroscience, Department of Psychology, Quinnipiac University, Hamden, Connecticut, United States of America, 3 Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America Abstract Social relationships have important effects on alcohol drinking. There are conflicting reports, however, about whether early- life family structure plays an important role in moderating alcohol use in humans. We have previously modeled social facilitation of alcohol drinking in peers in socially monogamous prairie voles. We have also modeled the effects of family structure on the development of adult social and emotional behaviors. Here we assessed whether alcohol intake would differ in prairie voles reared by both parents compared to those reared by a single mother. We also assessed whether meadow voles, a closely related species that do not form lasting reproductive partnerships, would differ in alcohol drinking or in the effect of social influence on drinking. Prairie voles were reared either bi-parentally (BP) or by a single mother (SM). BP- and SM-reared adult prairie voles and BP-reared adult meadow voles were given limited access to a choice between alcohol (10%) and water over four days and assessed for drinking behavior in social and non-social drinking environments.