the ras guanine nucleotide exchange factor rasgrf1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissueras鸟嘌呤核苷酸交换因子rasgrf1促进矩阵metalloproteinase-3生产类风湿性关节炎滑膜组织.pdfVIP

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the ras guanine nucleotide exchange factor rasgrf1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissueras鸟嘌呤核苷酸交换因子rasgrf1促进矩阵metalloproteinase-3生产类风湿性关节炎滑膜组织.pdf

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the ras guanine nucleotide exchange factor rasgrf1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissueras鸟嘌呤核苷酸交换因子rasgrf1促进矩阵metalloproteinase-3生产类风湿性关节炎滑膜组织

Available online /content/11/4/R121 Vol 11 No 4 Open Access Research article The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue Joana RF Abreu*, Daphne de Launay*, Marjolein E Sanders, Aleksander M Grabiec, Marleen G van de Sande, Paul P Tak and Kris A Reedquist Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands * Contributed equally Corresponding author: Kris A Reedquist, k.a.reedquist@amc.uva.nl Received: 13 May 2009 Revisions requested: 19 Jun 2009 Revisions received: 24 Jul 2009 Accepted: 13 Aug 2009 Published: 13 Aug 2009 Arthritis Research Therapy 2009, 11:R121 (doi:10.1186/ar2785) This article is online at: /content/11/4/R121 © 2009 Abreu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Fibroblast-like synoviocytes (FLS) from RA FLS by cDNA transfection and gene silencing, and effects rheumatoid arthritis (RA) patients share many similarities with on MMP-1, TIMP-1, MMP-3, IL-6, and IL-8 production measured transformed cancer cells, including spontaneous production of by ELISA. matrix metalloproteinases (MMPs). Altered or chronic activation of proto-oncogenic Ras family GTPases is thought to contribute Results Expression of RasGRF1 was significan