原创力文档the role of epidermal growth factor receptor mutations and epidermal growth factor receptor-tyrosine kinase inhibitors in the treatment of lung cancer表皮生长因子受体突变的作用,表皮生长因子受体酪氨酸激酶抑制剂治疗肺癌.pdfVIP
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the role of epidermal growth factor receptor mutations and epidermal growth factor receptor-tyrosine kinase inhibitors in the treatment of lung cancer表皮生长因子受体突变的作用,表皮生长因子受体酪氨酸激酶抑制剂治疗肺癌
Cancers 2011, 3, 2667-2678; doi:10.3390/cancers3022667
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
The Role of Epidermal Growth Factor Receptor Mutations and
Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors
in the Treatment of Lung Cancer
Shih-Chieh Chang 1, Cheng-Yu Chang 2 and Jin-Yuan Shih 3,*
1 Department of Internal Medicine, National Yang-Ming University Hospital, Yilan 260, Taiwan;
E-Mail: dtsurga9@.tw (S.-C.C.)
2 Department of Chest Medicine, Far Eastern Memorial Hospital, Taipei 220, Taiwan;
E-Mail: koala2716@ (C.-Y.-C.)
3 Department of Internal Medicine, National Taiwan University Hospital and College of Medicine,
National Taiwan University, Taipei 100, Taiwan
* Author to whom correspondence should be addressed: E-Mail: jyshih@.tw;
Tel: +886-2 Fax: +886-2
Received: 28 April 2011; in revised form: 1 June 2011 / Accepted: 7 June 2011 /
Published: 10 June 2011
Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide.
Non-small-cell lung cancer (NSCLC) cases comprise approximately 85% of the lung
cancer cases. Before the era of target therapy, platinum-based doublet chemotherapy only
led to a median survival of 8–9 months and a one-year survival of 30%–40% in patients
with advanced NSCLC. In July 2002, gefitinib, a small-molecule epidermal growth factor
receptor-tyrosine kinase inhibitor (EGFR-TKI), was approved for the treatment of patients
with advanced NSCLC in Japan. After the widespread use of gefitinib in the treatment of
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