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the role of mast cells in the defence against pathogens肥大细胞在防御病原体的作用
Pearls
The Role of Mast Cells in the Defence against Pathogens
1 1,2
Mirjam Urb , Donald C. Sheppard *
´ ´ ´ ´
1 Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, 2 Department of Medicine, McGill University, Montreal, Quebec, Canada
Although mast cells are best known for their role in mediating stimulation through TLR4 results in cytokine release alone [4].
allergic diseases, recent studies have highlighted the important role Furthermore, Dectin-1 binding of fungal b-glucan induces the
that these cells play in the protection against infection with a release of LTC4 by mast cells [5] while CD48 binds to the
variety of organisms. Escherichia coli adhesin FimH, and induces the release of TNF-a
[6].
What Are Mast Cells?
How Do Mast Cells Contribute to Host Defence?
Mast cells are leukocytes that are derived from haematopoietic
progenitor cells. They circulate in the blood in an immature form Mast cells are well placed to serve as immune sentinel cells to
before migrating to vascularised tissues, where they undergo final both respond directly to pathogens and send signals to other tissues
differentiation and maturation with the help of stem-cell factor to modulate both innate and adaptive immune responses
and other cytokines secreted by endothe
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