原创力文档the roles of parathyroid hormone-like hormone during mouse preimplantation embryonic development甲状旁腺激素种的角色在老鼠胚胎植入前的胚胎发育.pdfVIP
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the roles of parathyroid hormone-like hormone during mouse preimplantation embryonic development甲状旁腺激素种的角色在老鼠胚胎植入前的胚胎发育
The Roles of Parathyroid Hormone-Like Hormone during
Mouse Preimplantation Embryonic Development
1,2,3 1,2 1 1 1,2 1,3 1
Lei Guo , Shu-Tao Qi , De-Qiang Miao , Xing-Wei Liang , Hui Li , Xiang-Hong Ou , Xin Huang ,
1 1 1 1 1
Cai-Rong Yang , Ying-Chun Ouyang , Yi Hou , Qing-Yuan Sun , Zhiming Han *
1 State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, 2 Graduate School, Chinese Academy of Sciences,
Beijing, China, 3 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Abstract
Parathyroid hormone-like hormone (PTHLH) was first identified as a parathyroid hormone (PTH)-like factor responsible for
humoral hypercalcemia in malignancies in the 1980s. Previous studies demonstrated that PTHLH is expressed in multiple
tissues and is an important regulator of cellular and organ growth, development, migration, differentiation, and survival.
However, there is a lack of data on the expression and function of PTHLH during preimplantation embryonic development.
In this study, we investigated the expression characteristics and functions of PTHLH during mouse preimplantation
embryonic development. The results show that Pthlh is expressed in mouse oocytes and preimplantation embryos at all
developmental stages, with the highest expression at the MII stage of the oocytes and the lowest expression at the
blastocyst stage of the preimplantation embryos. The siRNA-mediated depletion of Pthlh at the MII stage oocytes or the 1
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