the secret(ion) life of worms的秘密生活(离子)蠕虫.pdfVIP

Minireview TThhee sseeccrreett((iioonn)) lliiffee ooff wwoorrmmss David McK Bird and Charles H Opperman Address: Center for the Biology of Nematode Parasitism, North Carolina State University, Raleigh, NC 27695, USA. Correspondence: David McK Bird. Email: david_bird@ Published: 28 January 2009 Genome BBiioollooggyy 2009, 1100::205 (doi:10.1186/gb-2009-10-1-205) The electronic version of this article is the complete one and can be found online at /2009/10/1/205 © 2009 BioMed Central Ltd AAbbssttrraacctt Tandem mass spectrographic analysis of the secreted proteins of plant- and human-parasitic nematodes reveals molecular similarities that reflect the shared need to counter host defenses. Nematodes are the most important parasites of plants and TThhee sseeccrreettoommee ooff MM.. iinnccooggnniittaa animals worldwide, contributing to human misery both Bellafiore et al. [5] exposed M. incognita larvae to root through direct infection and through losses to livestock and exudates followed by treatment with resorcinol, an agent agricultural crops. Driven largely by genome projects, several previously shown to induce copious expulsion of protein parasitic nematode species have emerged as model orga- from the pharyngeal glands via the feeding stylet. Following nisms. These include Brugia malayi [1], a filarial nematode this treatment, 486 secreted proteins were identified by parasitizing the lymphatic system and causing elephantiasis LC-MS-MS. These findings are significant for a number of in humans, and root-knot nematodes of the genus reasons, including the