the sedative effect of non-alcoholic beer in healthy female nurses不含酒精的啤酒的镇静效果在健康的女护士.pdfVIP

The Sedative Effect of Non-Alcoholic Beer in Healthy Female Nurses 1 ´ 1 1 ´ 1 1 2 Lourdes Franco , Cristina Sanchez , Rafael Bravo , Ana B. Rodrıguez , Carmen Barriga , Eulalia Romero , Javier Cubero 1,3* 1 Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain, 2 SES, Hospital Universitario Infanta Cristina, Badajoz, Spain, 3 Laboratory of Health Education, Science Education Area, University of Extremadura, Badajoz, Spain Abstract Introduction: The hop (Humulus lupulus L.), a component of beer, is a sedative plant whose pharmacological activity is principally due to its bitter resins, in particular to the a-acid degradation product 2-methyl-3-buten-2-ol. The mechanism of action of hop resin consists of raising the levels of the neurotransmitter c-aminobutyric acid (GABA), an inhibitory neurotransmitter acting in the central nervous system (CNS). Objectives: To analyze the sedative effect of hops as a component of non-alcoholic beer on the sleep/wake rhythm in a work-stressed population. Methods: The experiment was conducted with healthy female nurses (n = 17) working rotating and/or night shifts. Overnight sleep and chronobiological parameters were assessed by actigraphy (ActiwatchH) after moderate ingestion of non-alcoholic beer containing hops (333 ml with 0,0% alcohol) with supper for 14 days (treatment). Data were obtained in comparison with her own control