the stature of boys is inversely correlated to the levels of their sertoli cell hormones do the testes restrain the maturation of boys男孩的身高水平呈负相关的塞尔托利氏细胞激素睾丸抑制成熟的男孩.pdfVIP

The Stature of Boys Is Inversely Correlated to the Levels of Their Sertoli Cell Hormones: Do the Testes Restrain the Maturation of Boys? 1,2. 1. 2 2 1 Kirstie Morgan , Nicola A. Dennis , Ted Ruffman , David K. Bilkey , Ian S. McLennan * 1 Department of Anatomy Structural Biology, Brain Health Research Centre, University of Otago, Dunedin, New Zealand, 2 Department of Psychology, University of Otago, Dunedin, New Zealand Abstract The testes of preadolescent boys appear to be dormant, as they produce only trace levels of testosterone [1]. However, they ¨ ¨ release supra-adult levels of Mullerian Inhibiting Substance (MIS, anti-Mullerian hormone) and lesser levels of inhibin B (InhB), for unknown reasons [2,3]. Boys have a variable rate of maturation, which on average is slower than girls. The height of children relative to their parents is an index of their maturity [4,5]. We report here that a boy’s level of MIS and InhB is stable over time and negatively correlates with his height and his height relative to his parent’s height. This suggests that boy’s with high levels of MIS and InhB are short because they are immature, rather than because they are destined to be short men. The levels of MIS and InhB in the boys did not correlate with known hormonal modulators of growth, and were additive with age and the growth hormone/IGF1 axis as predictors of a boy’s height. If MIS and InhB were causal regulators of maturity, then the inter-boy differences in the levels of these hormone produces variation in maturation equivalent to 18- months of development. MIS and InhB may thus account for most of the variation in the rate of male devel