the tal effector ptha4 interacts with nuclear factors involved in rna-dependent processes including a hmg protein that selectively binds poly(u) rnatal效应ptha4与核因素参与依赖rna的过程包括一个hmg蛋白质选择性地结合保利(u)rna.pdfVIP

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2017-09-14 发布于上海
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the tal effector ptha4 interacts with nuclear factors involved in rna-dependent processes including a hmg protein that selectively binds poly(u) rnatal效应ptha4与核因素参与依赖rna的过程包括一个hmg蛋白质选择性地结合保利(u)rna.pdf

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the tal effector ptha4 interacts with nuclear factors involved in rna-dependent processes including a hmg protein that selectively binds poly(u) rnatal效应ptha4与核因素参与依赖rna的过程包括一个hmg蛋白质选择性地结合保利(u)rna

The TAL Effector PthA4 Interacts with Nuclear Factors Involved in RNA-Dependent Processes Including a HMG Protein That Selectively Binds Poly(U) RNA Tiago Antonio de Souza., Adriana Santos Soprano., Nayara Patricia Vieira de Lira, ´ ¤, Bianca Alves Pauletti, Adriana Franco Paes Leme, Alexandre Jose Christino Quaresma Celso Eduardo Benedetti* ´ ˆ Laboratorio Nacional de Biociencias (LNBio), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas, SP, Brazil Abstract Plant pathogenic bacteria utilize an array of effector proteins to cause disease. Among them, transcriptional activator-like (TAL) effectors are unusual in the sense that they modulate transcription in the host. Although target genes and DNA specificity of TAL effectors have been elucidated, how TAL proteins control host transcription is poorly understood. Previously, we showed that the Xanthomonas citri TAL effectors, PthAs 2 and 3, preferentially targeted a citrus protein complex associated with transcription control and DNA repair. To extend our knowledge on the mode of action of PthAs, we have identified new protein targets of the PthA4 variant, required to elicit canker on citrus. Here we show that all the PthA4-interacting proteins are DNA and/or RNA-binding factors implicated in chromatin remodeling and repair, gene regulation and mRNA stabilization/modification. The majority of these proteins, including a structural maintenance of chromosomes protein (CsSMC), a translin-associated factor X (CsTRAX), a VirE2-interacting protein (CsVIP2), a high mobility group (CsHMG) and two poly(A