氢饱和盐水对阿尔茨海默病模型大鼠神经保护作用及机制初步的研究.pdf

较多，氢饱和盐水治疗组则显著减少。免疫印迹分析结果显示模型组的JNK及 NF一1cB相对灰度值较假手术组明显增高，而氢饱和盐水治疗组则显著降低。 结 论 氢饱和盐水能显著改善Abeta蛋白诱导的阿尔茨海默病模型大鼠的学习记忆 功能障碍；可减少Abeta蛋白诱导的阿尔茨海默病模型大鼠海马及皮层脑组织神 经细胞脂质及核酸的氧化应激损伤；并能降低Abeta蛋白诱导的阿尔茨海默病模 型大鼠炎症因子含量及星形胶质细胞的活化而对其炎症反应损伤产生保护作用。 其机制可能通过抑制海马脑组织NF．rJ3，．INK等细胞信号通路的活化而发挥作用。 关键词：阿尔茨海默病；氢饱和盐水；Abeta蛋白；HNE；8-OH．dG； NF-r．B，JNK 3 ·英文论著摘要· Studiesonthe effectand neuroprotectiVegenral mechanismof salineon hydrogen--rich Alzheimer’Sdiseaserats Alzheimers themostcommoncauseof dementiain disease(AD)is progressive has the beenestimatedthatabout5％ofthe olderthan elderlypopulation．It population 65 isaffectedAlzheimersdisease．Thereisanenormousmedicalneedforthe years by ofnovel that the developmenttherapeuticstrategiestargetunderlyingpathogenic mechanisms．The mechanismsforAD includelossof proposedpathogenic generally function，oxidative cholinergic stress，amyloidcascade，inflammatorymediators， steroidhormone themthe cascade deficiencies，and excitotoxicity．Amongamyloid iswell which acentralroleofA13 inthe accepted hypothesis suggesting pathogenesis． Ithasbeenshownthataccumulationof ofthe 1—42 Ap 13-amyloid(inparticular peptide) inthebraininitiatesacascadeofeventsthat leadstoneuronal ul