低氧环境下蛋白酶体β5亚单位（PSMB5）过表达对人晶状体上皮细胞的影响及其作用机制实验的研究.pdfVIP

低氧环境下蛋白酶体且5弧单位(PSMB5)过表达对人品状体上皮细胞的影响及其作用机制的实验研究 the and of inthe trysin--likeactivityproteasome comparechymotrypsin··like Purpose：To ofhuman cataractandnormal orderto themechanismof epitheliumage—related lens，，in study inthe and cataract． the formation proteasome developmentofage—related lenswereobtained cataract of Methods：cataractous during surgeryZhongshan normal lenswereobtainedfrom Center，andage-matched Guangdongeye Ophthalmology bank． lens was Results：The ofnormal significantlyhi曲than proteasomeactivity epithelium the of lens of cataractous chymotrypsin—likeactivity proteasome epithelium(Po．01)；the corticalandnon—corticalcataracthadno 32Can inhibit difference(Po．05)；MG·1significantly the ofcataractousandnormallens． proteasomeactivity tonormal and trysin—likeactivity Conclusion：Comparedage—matchedlens，chymotrypsin—like of inthe of cataractlenswere declined， age—related significantly profeasomeepithelium thatthedecreaseofthe an roleinthe activitymayplayimportant indicating proteasome and cataract． formation developmentofa