血必净对脓毒症大鼠高迁移率族蛋白-1、IL-1β、IL-6和TNF-α表达的影响.pdf

血必净对脓毒症大鼠高迁移率族蛋白-1、IL-1β、IL-6和TNF-α表达的影响.pdf

was thatin atall lowerin C1 andDI than B time severitysignificantlyGroups Group thehalfsurvivaltimewas102hin C1and92hin D1.The points,and Group Group in C2andD2wassimilartothatin Bat24hor severity septic Groups Group less,but itdecreased at48—72 halfsurvivaltime hin C2 remarkablyh;the was76 and Group 78hinGroupD2. 2.EffectofEPand on HMGBlmRNA in Xuebijing expression hepatic tissue Therewasno differenceinHMGB1 mRNA atalltime significant expression in A.HMGB1 in Bwas tothatinother pointsGroup expression superior Group at24—48 h.Its wasobservedat24-72hin C1andD1 groups downexpression Groups as with B.HMGB1 in C2andD2 comparedGroup expressionGroups wassimilarto andlowerthanthatin Bat24hand48 wasnostatistical Group h,respectively;there differenceinHMGB1 betweenCand Dat72 expressionGroup Group h.Although HMGB1 mRNA was at72 was h,it expressiondownregulated significantly higher thanthatinother differencebet

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