八宝丹胶囊及苦黄注射液治疗病毒性肝炎各46例比较.docVIP

八宝丹胶囊及苦黄注射液治疗病毒性肝炎各46例比较 　【关键词】 病毒性肝炎；,,黄疸；,,八宝丹 　　摘要：目的比较八宝丹胶囊与苦黄注射液治疗急、慢性肝炎的临床疗效。方法92例病毒性肝炎患者，随机分为治疗组和对照组，每组46例，治疗组服用八宝丹胶囊0.6 g，3次/d；对照组服用苦黄注射液30 ml，3次/d；疗程4~6周。每周检查肝、肾功能。结果两组治疗后血清总胆红素和直接胆红素均较治疗前明显下降(P＜0.01)，谷丙转氨酶和谷草转氨酶均明显下降（P＜0.01)，两组间差异无显著性 (P＞0.05)，不良反应少。结论 八宝丹胶囊有良好的退黄、降酶作用，不良反应少，与苦黄注射液类似，可作为治疗病毒性肝炎的一线药物。 　　关键词：病毒性肝炎； 黄疸； 八宝丹 　　Babaodan Capsules (46 patients) vs Kuhuang Zhusheye (46 patients) in Treatment of Viral Hepatitis 　　Abstract：ObjectiveTo compare the effects of Babaodan Capsules and Kuhuang Zhusheye in treatment of viral hepatitis. Methods92 viral hepatitis patients were separated into two groups randomly, 46 in each group. The treatment group received Babaodan Capsules 0.6 g, 3 times per day; the comparing group received Kuhuang Zhusheye 30 ml, 3 times per day. The courses of treatment were 4~6 weeks. Functions of liver and kidney were checked weekly. ResultsAfter treatment serum total bilirubin (STIB) and serum direct bilirubin (SDIB)of two groups came down obviously than that of before treatment(Plt;0.01),ALT and AST came down obviously(Plt;0.01), there was not obvious discrepancy between two groups (Pgt;0.05), unhealthy reactions were slight. ConclusionBabaodan Capsules has good effect in decreasing jaundice and aminotransferase with rare adverse reaction as well as Kuhuang Zhusheye. 　　Key words：Viral Hepatitis; Jaundice cholestatis; Barbadian 　　病毒性肝炎主要是由病毒感染引起的急、慢性炎症，以皮肤、巩膜出现黄染，尿黄，伴或不伴乏力，纳差，肝区疼痛，肝功能检查胆红素升高、转氨酶异常为主要表现的常见临床疾病。目前临床常用思美泰、门冬氨酸钾镁、苦黄注射液、茵栀黄注射液、丹参注射液等，其中苦黄注射液疗效肯定，不良反应小，价格低廉，临床已广泛应用［1］。但以上药物均只能静脉给药，临床使用受到限制，特别在门诊使用十分不便。厦门中药厂生产的八宝丹胶囊（Babaodan Capsules）是治疗湿热症的病毒性肝炎的传统名药［2］，我们于200406~200506在烟台市传染病医院应用八宝丹胶囊治疗病毒性肝炎46例，疗效较好，并与苦黄注射液进行比较。现报道如下。 　　1 资料与方法 　　1.1 一般资料病毒性肝炎患者92例，治疗组46例，男28例，女18例；年龄（46±10）岁。对照组46例，男，26例，女20例；年龄（45±12）岁，两组性别、年龄、病型、病程及肝功能等差异无显著性，具有可比性（P＞0.05）。结果见表1。表1 两组一般资料比较组（略） 　　1.2 诊断标准参照2000年西安会议“病毒性肝炎防治方案”［3］标准。（1）症状：目黄、身黄、尿黄、2周内出现极度乏力、消化道症状明显；（2）实验室检查：血清总胆红素(TBIL)＞17.1 μmol/L或尿胆红素、尿胆原均为阳性，并排除其他原因引起的黄疸；同时谷丙转氨酶（ALT）≥40 IU/L，血清肝炎